Prescription glasses should be handled with care to increase their longevity and usefulness. To reduce the chances of misaligning or twisting the arms of the prescription glasses, one should always use both hands to put on the prescription glasses and also while taking them off. You should also check regularly for any such misalignments.
When you find that your prescription glasses run asymmetric on your nose, there is a good chance that these prescription glasses are misaligned. Though it will be wise to get a professional to look at it, you can also purchase a toolkit for prescription glasses and use it for emergencies. If the lenses fall off your prescription glasses, one should always get them checked by a trained optician.
In the event of wiping or cleaning the lenses, first you need to rinse them off in water. Even the smallest particles can be dangerous when rubbed across the lens surface. This is one of the major reasons of rendering prescription glasses useless. One should never use chemicals not specifically designed for lenses. Always a soft, clean cloth (preferably 100% cotton or microfiber cloth) must be used to wipe the lens surface after the prescription glasses are rinsed or cleaned. And it goes without saying that the prescription glasses should be never placed face down and should always be stored in a case when not in use.